Learn more about Materials Research at CU:
- Chemistry and Biochemistry
- Mechanical Engineering
- Chemical and Biological Engineering
- Liquid Crystal Materials Research Center
- Electrical, Computer, and Energy Engineering
Selected Research from MSE Faculty, Fellows, and Affiliates:
Rational Design of Ultrastable Microbubbles
Professor Mark Borden, Department of Mechanical Engineering
The goal of this study was to increase in vivo microbubble circulation persistence for applications in medical imaging and targeted drug delivery. Our approach was to modulate the inter-lipid van der Waals cohesive forces by varying acyl chain length, while holding constant the microbubble size, concentration and surface architecture. We observed an increase in microbubble stability correlating with the” wrinkling transition”, which is the onset of significant surface shear viscosity and gas permeation resistance. However, we also observed a precipitous drop in stability for very long acyl chains, suggesting that hydrophobic mismatch between the matrix lipid and lipopolymer emulsifier drives a less stable surface microstructure. Overall, we achieved an over 20-fold increase in circulation half-life compared to current commercially available microbubble ultrasound contrast agents.
Professor Borden was invited to present this work in England at the Leeds Microbubble Symposium.