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Selected Research from MSE Faculty, Fellows, and Affiliates:

Systemic oxygen delivery by peritoneal perfusion of oxygen microbubbles

Professor Mark Borden, a Fellow of the MSE program, and his collaborator Ben Terry (CU-Boulder, class of 2011), now an Assistant Professor at the University of Nebraska, have invented a novel way to oxygenate hypoxemic patients who cannot breath.  Their method is to pump oxygen microbubbles into the peritoneal cavity to deliver oxygen and remove carbon dioxide.  “The system is analogous to an umbilical cord: it delivers to the abdomen life-sustaining oxygen, where it can be transported by the patient’s circulatory system to the brain and other vital organs.  The microbubbles also absorb and remove unwanted carbon dioxide from the patient.  Our preliminary studies show that the technology provides oxygen and allows time for the lung injury to heal.  This is a major advance over our prior method of introducing oxygen microbubbles directly into the bloodstream.  It is much safer and simpler to implement, giving it a more straightforward pathway for clinical translation.”  The oxygen microbubbles were designed by Borden to have the properties of the lung alveoli, with a nanoscale lipid layer that provides mechanical stability to support a large, permeable surface for enhanced gas exchange.  In their landmark study, now published in Biomaterials, they showed safety and efficacy of the approach in a preclinical trial for severe lung injury.  “We are currently doing preclinical trials to test safety and efficacy for the treatment of acute respiratory distress syndrome,” says Borden.  “Our next step will be to translate this technology to the clinic.”